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IC50 and Ki values of the AKR1B10-catalysed farnesal reduction in the presence of the inhibitors XN, IX and 8-PN.
| Enzyme | Parameter | XN | IX | 8-PN |
|---|---|---|---|---|
| AKR1B10 | IC50 [μM] | 41.37 ± 6.86 | 4.24 ± 0.23 | 3.96 ± 0.17 |
| Ki [μM] | 20.11 ± 3.73 | 2.25 ± 0.24 | 1.95 ± 0.12 |
Farnesal concentration is equal to the KM (5 μM). Data are presented as mean ± standard deviation from at least three experiments.
XN: xanthohumol; IX: isoxanthohumol; 8-PN: 8-prenylnaringenin.
