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. 2018 Mar 7;33(1):560–566. doi: 10.1080/14756366.2018.1441839

Figure 1.

Figure 1.

Dose–response curves determined in the hot-plate test for the inhibition of jumping induced by i.c.v. injection of EM-2 and cyclic analogs C-36 and F-81 (Panel A). Effects induced by peptides after i.v. administration at the dose of 20 mg/kg (Panel B). The antagonist effect of β-funaltrexamine (β-FNA, 1 µg/animal, i.c.v.), naltrindole (NTL, 1 µg/animal, i.c.v.), and nor-binaltorphimine (nor-BNI, 5 µg/animal, i.c.v.), on the inhibition of jumping induced by F-81 (10 ng/animal, i.c.v.) (Panel C). *** is for p <.001 for agonist + β-FNA versus agonist alone using two-way ANOVA, followed by the Student–Newman– Keuls test. The data represent mean ± SEM of 10 mice per group.