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Blood–brain barrier permeability (PAMPA) results for cyclic pentapeptide analogs.
| Compound | BBB permeability Pe (10−6 cm−1) ± SD | Mean (%) Mass balance ± SD | Classification |
|---|---|---|---|
| Verapamil | 29.9 ± 6.5 | 89.28 ± 2.35 | High permeation |
| Theophylline | ≤0.58 | 98.21 ± 3.65 | Low permeation |
| C-36 | ≤0.58 | 97.87 ± 1.69 | Low permeation |
| F-81 | ≤0.58 | 95.75 ± 1.43 | Low permeation |
