Table 1.

hCA I, II and MgCA inhibition data with MTCs 1−15, trithiocarbonate 16 and xanthate 17 by a stopped-flow CO₂ hydrase assay⁶³.

			KIa
No.	R	R1	hCA I (nM)	hCA II(nM)	MgCA (µM)
1b	H		891	26.7	14.1
2b	H		>2000	43.7	18.9
3b	H		>2000	35.0	7.81
4b	n-Pr	n-Pr	>2000	46.7	1.85
5b	n-Bu	n-Bu	909	>2000	7.52
6b	i-Bu	i-Bu	681	43.0	8.61
7b	Et	n-Bu	700	>2000	5.26
8b	Me		827	44.5	9.16
9b	Me	Bn	>2000	>2000	7.61
10b	–(CH2CH2)–O–(CH2CH2)–		569	>2000	7.65
11b	–(CH2CH2)–NH–(CH2CH2)–		876	22.4	7.41
12b	–(CH2CH2)–N(4–F–C6H4)–(CH2CH2)–		895	46.8	8.33
13b	–(CH2CH2)–N(4–CF3–C6H4)–(CH2CH2)–		>2000	43.6	4.22
14b	–(CH2CH2)–N(3–Cl–C6H4)–(CH2CH2)–		686	>2000	15.9
15b	–(CH2CH2)–N(CH2CONHC6H11)–(CH2CH2)–		949	45.9	6.13
16b	Bn	–	4.1	0.70	8.12
17b		–	64.1	5.4	16.2
AAZ			250	12	74

^aMean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values); ^bhCA I and hCA II data from Ref.^14f.