Table 3.

In vitro IC₅₀ values of the designed compounds towards EGFR kinase enzyme.

	% Inhibition
Compd no.	10.0a	5.0a	2.5a	1.25a	0.625a	0.31a	0.15a	EGFR IC50 (μM)
6a	57.65	50.34	44.35	34.55	26.84	18.16	6.67	4.66
6b	83.66	76.71	64.44	61.23	55.33	48.95	26.52	0.56
7	72.78	65.98	52.86	49.65	43.27	31.78	8.22	1.6
8b	64.88	60.72	50.51	47.28	43.85	26.25	6.96	2.16
Sorafenib	80.88	71.63	56.72	49.48	43.27	33.92	10.82	1.28

^aConcentarion in μM.