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PKM2 inhibitory activity of compounds 3a-3h.
 | ||
|---|---|---|
| Compound | R | IC50 ± SD (μM) |
| 3a | morpholinyl | 2.64 ± 0.98 |
| 3b | dimethylamino | >10 |
| 3c | diethylamino | 2.78 ± 0.97 |
| 3d | di-n-propylamino | 3.08 ± 1.23 |
| 3e | diallylamino | >10 |
| 3f | thiamorpholinyl | 1.05 ± 0.17 |
| 3g | pyrrolidinyl | 2.33 ± 0.52 |
| 3h | thiazolidinyl | 0.96 ± 0.18 |
| 3k | 2.95 ± 0.53 | |
| Shikonin | 8.82 ± 2.62 | |
