Table 2.
IC50 ± SDa (μM) |
|||||
---|---|---|---|---|---|
compd | HCT116 | MCF7 | Hela | H1299 | B16 |
3a | 0.214 ± 0.003 | 0.340 ± 0.003 | 0.337 ± 0.054 | 0.331 ± 0.091 | 0.272 ± 0.010 |
3b | 0.088 ± 0.004 | 0.069 ± 0.009 | 0.122 ± 0.017 | 0.109 ± 0.002 | 0.104 ± 0.011 |
3c | 0.093 ± 0.002 | 0.084 ± 0.003 | 0.251 ± 0.059 | 0.144 ± 0.013 | 0.108 ± 0.010 |
3d | 0.597 ± 0.014 | >10 | >10 | 0.830 ± 0.162 | 0.787 ± 0.203 |
3e | 0.742 ± 0.045 | 1.092 ± 0.421 | 3.456 ± 3.188 | 1.019 ± 0.111 | 0.709 ± 0.027 |
3f | 0.189 ± 0.035 | 0.194 ± 0.055 | 0.412 ± 0.018 | 0.206 ± 0.018 | 0.189 ± 0.006 |
3g | 0.164 ± 0.003 | 0.638 ± 0.020 | 0.298 ± 0.053 | 0.247 ± 0.015 | 0.159 ± 0.002 |
3h | 0.374 ± 0.015 | 0.234 ± 0.045 | 1.126 ± 0.080 | 0.306 ± 0.008 | 0.317 ± 0.022 |
Shikonin | 1.060 ± 0.182 | 2.405 ± 0.346 | 0.813 ± 0.081 | 0.954 ± 0.186 | 1.220 ± 0.155 |