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. 2017 Jan 19;32(1):478–489. doi: 10.1080/14756366.2016.1261132

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Representative graphs of glutathione cycle in liver of Wistar rats intact and administered Cd, DSF and a combination of both substances. *See the experimental conditions presented in the section Experimental design. Values are presented as means ± S.D. Labels of statistical significance: compared with the control group (*) and compared with Cd42 subgroup (°). Statistical significance was considered at: ∗p < 0.01, ∗∗p < 0.001, ∗∗∗p < 0.0001 and °°°p < 0.0001. (A, B) Reduced and oxidized glutathione content: presented parameters of antioxidative defence (obtained values, expressed in μM, were recalculated in regard to protein status and expressed as nmol GSH or GSSG/mg proteins for the appropriate discussion of the obtained results). (C) Ratio of oxidized and reduced glutathione: presented parameter of glutathione homeostasis (values are presented as means of GSSG/GSH ratio through chosen time points). (D) GR activity: presented parameter of antioxidative defence (expressed as U GR/mg proteins). (E) GST activity: presented parameter of antioxidative defence (expressed as U GST/mg proteins). (F) GPx activity: presented parameter of antioxidative defence (expressed as U GPx/mg proteins).