Table 3.

Effect of compound 6n on the active caspases-3, -8 and -9 levels, and the expression levels of Bcl-2, Bax and cytochrome C, respectively, in MCF-7 cancer cells treated with the compound at its IC₅₀ concentration.

Compound	Casp-3 IU/ml	Casp-8 IU/ml	Casp-9 IU/ml	Bax IU/ml	Bcl-2 IU/ml	Bax/Bcl-2 ratio	Cyt-C IU/ml
Control	1733	3368	246	985	178,233	0.0055	660
6n	131,927***	6690**	228,320***	374,152***	165,783**	2.256	383,873***

Data are mean ± SD of three separate experiments.

^*Significantly different from control (1% DMSO) at p < .05.

^**Significantly different from control at p < .01.

^***Significantly different from control at p < .001.