Table 5.
Oxidative stress markers and antioxidants in control and MCF-7 treated cells with compounds 6i, 6j, 6n and 6q.
| Compound |
|||||
|---|---|---|---|---|---|
| ROS | 6i | 6j | 6n | 6q | Control |
| Total protein (μg/106 cells) | 59.1 ± 7.5 | 89.2 ± 10.4 | 54.6 ± 8.2 | 70.8 ± 6.4 | 131.9 ± 11.7 |
| Superoxide dismatase (SOD) (nMol/mg protein) | 137.8 ± 12.4 | 104.6 ± 7.8 | 145.2 ± 9.6 | 114.5 ± 10.1 | 64.6 ± 2.8 |
| Catalase (CAT) (U/mg protein) | 8.7 ± 2.9 | 22.6 ± 1.2 | 10.9 ± 4.1 | 18.4 ± 1.8 | 24.8 ± 3.4 |
| Glutathione peroxidase (GSHPx) (mU/mg protein) | 4.9 ± 1.3 | 6.7 ± 1.5 | 4.6 ± 0.8 | 5.3 ± 1.1 | 8.9 ± 1.8 |
| Malondialdehyde (MDA) (nMol/mg protein) | 1.75 ± 0.31 | 0.56 ± 0.18 | 1.68 ± 0.24 | 1.27 ± 0.15 | 0.42 ± 0.06 |
| Protein carbonyl (PC) (mMol/mg protein) | 16.8 ± 2.4 | 8.4 ± 0.4 | 28.1 ± 3.7 | 12.3 ± 1.5 | 6.4 ± 0.2 |
Data are mean ± SD of three separate experiments.