Table 1.
Inhibition of human CDC25 isoforms by quinones and quinone-like compounds 1, and 3–5.
IC50 (μM)* |
|||
---|---|---|---|
Mol | CDC25A | CDC25B | CDC25C |
1 | 2.64 ± 0.62 | 6.99 ± 0.21 | 5.72 ± 0.27 |
3 | 3.19 ± 1.02 | 11.13 ± 1.01 | 5.41 ± 0.52 |
4 | 3.73 ± 1.53 | 18.20 ± 1.68 | 9.43 ± 1.25 |
5 | 2.53 ± 0.23 | 7.46 ± 2.17 | 5.76 ± 0.42 |
Values are expressed as mean of triplicates ± standard deviation (SD).