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. 2017 Oct 26;32(1):1305–1312. doi: 10.1080/14756366.2017.1386660

Table 1.

In vitro hCA I, hCA II, hCA IV, hCA VII, and hCA IX activation data with histamine Schiff bases H(1–20) by a stopped-flow CO2 hydrase assay.

  KA (µM)a
Comp.H hCA I hCA II hCA IV hCA VII hCA IX
1 18.4 54.2 47.1 20.6 31.4
2 1.60 21.7 0.0018 21.9 7.81
3 0.85 36.8 1.24 0.81 15.8
4 0.24 37.9 1.03 0.052 39.9
5 1.17 34.2 2.15 0.061 26.4
6 1.02 25.8 1.70 0.012 41.7
7 0.94 14.5 1.86 0.038 20.5
8 0.80 8.62 0.93 0.006 31.8
9 2.83 9.27 0.96 0.012 30.0
10 4.14 10.4 1.51 0.007 62.6
11 10.7 21.9 36.8 12.6 65.4
12 8.52 11.2 18.9 24.6 47.9
13 11.2 24.3 25.7 7.13 48.1
14 12.7 21.2 33.5 11.4 51.2
15 20.4 45.2 29.1 8.23 49.0
16 24.3 30.7 20.0 7.16 47.9
17 14.1 58.9 24.1 6.26 31.6
18 9.64 63.4 28.3 9.51 47.9
19 17.8 44.5 29.0 8.44 58.2
20 10.4 41.8 30.5 0.78 57.6
HST 2.10 125 4.03 37.6 35.2

Histamine (HST) has been used as standard activator42.

a

Mean from three different determinations (errors in the range of 5–10% of the reported values, data not shown).