Table 2.

Median growth inhibitory (GI₅₀, μM), total growth inhibitory (TGI, μM), and median lethal (LC₅₀, μM) concentrations of compounds 7 and 19 on in vitro subpanel tumour cell lines.

	Subpanel tumour cell lines
Compd.	Activity	Leukaemia	NSC lung cancer	Colon cancer	CNS cancer	Melanoma	Ovarian cancer	Renal cancer	Prostate cancer	Breast cancer	MG-MIDa
7	GI50	68.28	8.11	30.82	4.33	12.26	8.86	5.76	17.40	5.30	17.90
	TGI	b	40.56	85.81	15.28	57.06	37.30	30.41	b	30.46	55.20
	LC50	b	80.22	89.76	46.10	78.12	80.95	64.80	b	84.75	80.52
19	GI50	4.57	8.95	5.47	4.62	5.25	8.07	6.62	9.03	4.47	6.33
	TGI	93.44	63.45	73.35	63.85	49.74	56.50	65.06	b	70.50	70.65
	LC50	b	96.36	88.55	64.62	b	92.75	b	b	b	93.58
5-FU	GI50	15.10	b	8.40	72.10	70.60	61.40	45.60	22.70	76.40	18.60
	TGI	b	b	b	b	b	b	b	b	b	b
	LC50	b	b	b	b	b	b	b	b	b	b

^aFull panel mean-graph midpoint (μM).

^bCompounds showed values >100 μM.