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. Author manuscript; available in PMC: 2018 Jun 20.
Published in final edited form as: Acc Chem Res. 2009 Jul 21;42(7):915–924. doi: 10.1021/ar8002738

FIGURE 8.

FIGURE 8

(Eu–DOTA-Gly)41–G5PAMAM (Eu–G5) and (Yb–DOTA-Gly)6–G2PAMAM (Yb–G2) were injected i.v. at 0.03 mmol of dendrimer per kilogram of mouse body weight into a xenograft flank mouse model of MCF-7 mammary carcinoma.32 (A) MR images were acquired by prepending a 20 μT saturation period for 2.25 s before a RARE-16 MR signal acquisition period. Selective saturation was applied at the PARACEST frequency of each agent. (B) The decrease in MR signal of the tumor after injection relative to the average MR signal before injection was used to measure the temporal change in the CEST effect. (C) Equation 11 was used to calculate the concentration ratio of the CEST agents.