Fig. 5.

TSA protection against cerebral ischemia is absent in Nrf2-deficient mice. Nrf2^−/− mice had increased infarct volume compared to WT counterparts in the absence of TSA (A), and also had more neurological deficits than WT mice, but no statistical significance (C). TSA treatment (1 mg/kg) had no effect on cortical infarct volume or neurologic deficit scores in Nrf2^−/− mice compared to vehicle-treated controls (B and D); n=10 per group.