Table 3.
Summary of results from hierarchical linear regression models predicting Nucleus Accumbens activation during high and low reward/loss anticipation for each of the 5 clusters.
| Cluster Distance to TSS | Nucleus Accumbens | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High Reward | Low Reward | High Loss | Low Loss | ||||||||||||||
| ALC | HC | ALC | HC | ALC | HC | ALC | HC | ||||||||||
| β | p | β | p | β | p | β | p | β | p | β | p | β | p | β | p | ||
| A | -1101 to -886 | -.05 | .782 | -.10 | .510 | -.08 | .619 | -.13 | .411 | .12 | .471 | -.33 | .028 | .21 | .205 | -.31 | .057 |
| B | -423 to -321 | -.05 | .780 | -.12 | .444 | -.10 | .531 | -.06 | .702 | .01 | .941 | -.26 | .110 | -.04 | .804 | -.30 | .069 |
| C | 29042 to 29089 | .21 | .167 | .23 | .137 | .13 | .399 | .137 | .377 | .09 | .565 | .15 | .345 | .02 | .920 | -.04 | .801 |
| D | 29188 to 29292 | -.11 | .478 | .04 | .817 | -.05 | .769 | .12 | .513 | -.17 | .267 | .17 | .359 | -.12 | .429 | .29 | .126 |
| E | 50868 to 50969 | .14 | .366 | -.18 | .246 | .19 | .221 | -.24 | .123 | -.11 | .476 | -.19 | .226 | .05 | .765 | -.16 | .331 |
Note: ALC = alcohol-dependent group, HC = healthy control group. Boldface indicates significant differences between ALC and HC group as indicated by a significant interaction between group and cluster methylation in linear regression model (alpha set at p < .05).