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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Pharmacogenet Genomics. 2018 Jul;28(7):179–187. doi: 10.1097/FPC.0000000000000341

Table 4.

Associations between baseline plasma total bilirubin concentration and predicted gene expression levels in liver.

Race/ethnicity Gene Chromosome Participants Beta P value
All UGT1A1 14 1354 0.30 3.4×10−27
GGACT 2 1354 −0.88 7.2×10−6
White UGT1A1 2 645 0.32 4.28×10−15
CSN1S1 4 645 −0.37 8.72×10−5
Black UGT1A1 2 458 0.30 4.2×10−12
PGBD2 1 458 −1.96 3.57×10−5
Hispanic CLDN12 7 282 −4.17 3.69×10−7
UGT1A1 2 282 0.33 1.45×10−6

Linear regression analysis involved numbers of participants shown, for baseline plasma total bilirubin concentration. Analysis among all participants controlled for CYP2B6/CYP2A6 genotype level, age, and sex. Analysis among white, black, and Hispanic participants controlled for the same covariates but did not control for principal components. The two lowest P-value results are shown for each population group.