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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Neurobiol Aging. 2018 Apr 4;68:26–33. doi: 10.1016/j.neurobiolaging.2018.03.031

Figure 3. Late-life fractional anisotropy and mean diffusivity according to 21-year C-reactive protein trajectory.

Figure 3

Estimated late-life total brain (A, B) fractional anisotropy and (C, D) mean diffusivity according to the trajectory of C-reactive protein levels from mid- to late-life in the (A, C) primary analysis of the total sample and (B, D) after accounting for differential attrition due to death and drop-out using inverse probability of attrition weighting. Models are adjusted for age, sex, race-center, education, cigarette smoking and alcohol use status, BMI, total cholesterol, HDL, hypertension, diabetes, coronary heart disease, previous cancer, inflammatory disease, anti-inflammatory medication use, and APOE ε4 status.

*P < .05; ** P < .01 difference between group and the Stable Low (referent) group

Abbreviations: FA = fractional anisotropy; IPAW = inverse probability of attrition weighting; MD = mean diffusivity.