Table 2. Frequency of PTPN22 gene functional variant (C1858T, rs2476601) genotypes and alleles in Kuwaiti TIDM patients and controls patients and controls (for details please see Patients and methods).
| Genotype/Alleles | TIDM Patients N = 253 (%) | Controls N = 214 (%) | OR (95% CI)* | P-value** |
|---|---|---|---|---|
| Co-dominant | ||||
| CC | 160 (63) | 180 (84) | 1.00 (Reference)a | |
| CT | 76 (30) | 32 (15) | 2.67 (1.68–4.25) | <0.001 |
| TT | 17 (7) | 2 (1) | 9.56 (2.18–42.0) | <0.001 |
| Dominant | ||||
| CC | 160 (63) | 180 (84) | 1.00 (Reference)a | |
| CT/TT | 93 (37) | 34 (16) | 3.08 (1.97–4.81) | <0.001 |
| Alleles | n = 506 (%) | n = 428 (%) | ||
| C | 396 (78) | 392 (92) | 1.00 | |
| T | 110 (22) | 36 (8) | 3.03 (2.03–4.52) | <0.001 |
*OR (95% CI), odds ratio at 95% confidence interval;
**P-values were considered significant when <0.05.
a Genotype frequency in the case of homozygous CC subjects and allele frequency of ‘C’ were considered as reference (assuming to be associated with least risk of T1DM) for calculation of statistical significance using Fisher’s Exact test.