Table 6. Correlation of autoantibody-positivity with genotypes of PTPN22 gene functional variant (C1858T, rs2476601) in Kuwaiti TIDM patients stratified on the basis of age-of-onset of the disease.
ICA, Islet cell autoantibody; GADA, glutamic acid decarboxylase autoantibody; INS, insulin autoantibody.
| Age-of-onset group/ Autoantibody | Autoantibody/ Frequency Genotype | Autoantibody/ Frequency Genotype | Autoantibody/ Frequency Genotype | |||
|---|---|---|---|---|---|---|
| CC | (%) | CT | (%) | TT | (%) | |
| ICA Autoantibody | ||||||
| <4 years | 23/34 | (68) | 7/10 | (70) | 2/4 | (50) |
| 4–6 years | 23/40 | (58) | 11/15 | (73.3) | 6/8 | (75) |
| >6 years | 41/82 | (50) | 25/50 | (50) | 3/5 | (60) |
| GADA Autoantibody | ||||||
| <4 years | 28/34 | (82.4) | 7/10 | (70) | 4/4 | (100) |
| 4–6 years | 33/40 | (83) | 14/15 | (93.3) | 8/8 | (100) |
| >6 years | 69/82 | (84) | 40/50 | (80) | 5/5 | (100) |
| INS Autoantibody | ||||||
| <4 years | 29/34 | (85.3) | 8/10 | (80) | 1/4 | (25) |
| 4–6 years | 28/40 | (70) | 12/15 | (80) | 7/8 | (88) |
| >6 years | 56/82 | (68.3) | 31/50 | (60) | 4/5 | (80) |