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. 2018 Jun 20;13(6):e0199517. doi: 10.1371/journal.pone.0199517

Fig 4. ARQ-197 reduces the number of osteolytic lesions and prevents the loss of trabecular bone in JJN3 tumour-bearing mice.

Fig 4

(A) Representative μCT 3D and (B) cross-sectional images of tibiae or (C) vertebrae (L3) from naïve mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). (D) Lesion counts (Lesions NO) and (E) trabecular bone fraction (BV/TV %) analysed by μCT of the tibiae or (F) vertebrae (L3) from naïve mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). All data displayed as mean ± SD and analysed using a normal one-way ANOVA, where significance is indicated by *P<0.05, **P<0.01, ***P<0.001 or ****P<0.0001.