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. 2018 Jun 20;13(6):e0199517. doi: 10.1371/journal.pone.0199517

Fig 7. ARQ-197 inhibits bone formation loss on the cortico-endosteal surface of the tibiae from JJN3 tumour-bearing mice.

Fig 7

Representative images of bone formation on the, cortico-endosteal surfaces, (A) magnification x4 (scale bar = 500 μm) and (B) magnification x20 (scale bar = 100 μm) of tibiae from naïve mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). Histomorphometric analysis of (C) the mineralising surface (MS, %) (D) the mineral apposition rate (MAR, μm/day) and (E) the bone formation rate (BFR/BS, mm2 X 10−3/mm/day) on the cortico-endosteal bone surface of tibiae from naive mice (Naïve) and tumour-bearing mice treated with vehicle (JJN3) or ARQ-197 (JJN3+ARQ-197). All data displayed as mean ± SD and analysed using a normal one-way ANOVA, where significance is indicated by *P<0.05, ***P<0.001 or ****P<0.0001.