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. 2018 May 29;7:e33092. doi: 10.7554/eLife.33092

Figure 3. Rem2 is required for late-phase critical period ocular dominance plasticity.

Figure 3.

(A) Representative experimental timeline for (top) critical period ocular dominance (OD) plasticity and (bottom) adult OD plasticity. (B) Example fields showing intrinsic signal imaging data from the ipsilateral (I) and contralateral (C) eyes in wildtype or Rem2-/- mice that were (left) typically reared (TR) or monocularly deprived (MD) for 2 days (middle) and 6 days (right). (C) Ocular dominance index (ODI) for WT TR (black, n = 6), WT 2d MD (dark gray, n = 6), WT 6d MD (light gray, n = 6), Rem2-/- TR (blue, n = 6), and Rem2-/- 2d MD (medium blue, n = 9), Rem2-/- 6d MD (light blue, n = 7). Mice are shown as circles for each animal. Orange circles with error bars represent the group averages. Inset at bottom: Changes in reflectance over baseline reflectance (ΔR/R) as measured by ISI driven ipsilateral (I) or contralateral (C) eye for wildtype and Rem2-/- mice that were either typically reared or monocularly deprived. (D) ODI for Adult WT TR (black, n = 12), Adult WT MD (gray, n = 6), Adult Rem2-/- TR (navy blue, n = 6), and Adult Rem2-/- MD (gray blue, n = 8). Inset: ΔR/R for Adult WT and Rem2-/- TR and MD mice. Data is presented as mean ± SEM. *p<0.05 by two-way ANOVA and Tukey post-hoc. Significance comparisons for ΔR/R in C and D insets are listed in Table 1.