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. 2018 Jun 20;8:9411. doi: 10.1038/s41598-018-27779-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of whole blood flow in the co-flow microfluidic systems. (a) Shear induced diffusion of blood cells leads to expansion of blood streams. (b) Modified velocity and shear rate profiles within channel cross-section at start position obtained from numerical simulation (ESI Group, ACE+). Dashed lines represent the interfaces of the two adjacent fluids. (c) Interface between blood and saline streams. Channel length was 10 mm. Each micrographs was generated from the standard deviation of 500 bright field images.