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. 2018 Jun 20;8:9419. doi: 10.1038/s41598-018-26867-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Three-group comparisons of TL in (A) PBMC, (B) naïve T helper cells, (C) memory T helper cells, (D) naïve cytotoxic T cells, and (E) memory cytotoxic T cells between non-depressed control subjects with (N = 4, filled circles) and without CSA (N = 17, open circles), MDD patients without CSA (N = 12, open squares), and MDD patients with CSA (N = 6, filled squares) revealed a stepwise decrease in TL in naïve and memory cytotoxic T cells, with the shortest TL in MDD patients with CSA. CSA, childhood sexual abuse; kb, kilobase; MDD, Major Depressive Disorder; PBMC, peripheral blood mononuclear cells; TL, telomere length. *p < 0.05, **p < 0.01 (Tuckey post-hoc comparisons).