Table 2.

Treatment related grade 3–5 AEs per study arm

Adverse event	Supplemented patients (n = 41), n (%)			Non-supplemented patients (n = 41), n (%)
	Grade			Grade
	3	4	5	3	4	5
Febrile neutropenia	2 (5)			1 (2)
Leukopenia	9 (22)			4 (10)
Trombopenia	4 (10)	3 (7)		4 (10)	1 (2)
Anemia	6(15)			2 (5)
Fatigue	4 (10)			10 (24)
Cardiac	1 (2)			1 (2)		2 (5)
Neurologic	1 (2)	2 (5)		5 (12)
Ototoxicity				1 (2)
Pulmonary				1 (2)
Nausea	4 (10)			3 (7)
Vomiting	2 (5)			2 (5)
Anorexia	2 (5)			5 (12)
Liver	1 (2)
Diarrhea				1 (2)
Pain				1 (2)
Skin	1 (2)
Renal/bladder	5 (12)
Hemorrhage	1 (2)	1 (2)		2 (5)
Infection	1 (2)			1 (2)

Percentages are rounded to whole numbers. For each grade 3/4/5 adverse event the maximum toxicity was noted per patient