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. 2018 Jun 14;9:447. doi: 10.3389/fneur.2018.00447

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Copyright © 2018 Avezov, Aizenbud and Lavie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of intermittent and sustained hypoxia in vitro on EC-CFUs number and area with and without treatment with apocynin or diphenyl iodide (DPI). (A) Mean EC-CFUs numbers on the 7th day in culture with and without apocynin (100 μM) or diphenyl iodide (DPI) (5 μM) (n = 8). Control cells were exposed for 3 days to intermittent hypoxia (IH) and sustained hypoxia (SH) as specified in Methods and compared to normoxia (Norm). Additional cell cultures were exposed to apocynin or DPI concomitantly with Norm, IH and SH. (p < 0.008 for: Norm vs. IH, IH vs. IH+apocynin). Following DPI treatment no cellular maturation and no EC-CFUs formation was noted. (B) Mean EC-CFU size on the 7th day in culture with and without apocynin (n = 8) was unaffected. No significant differences were found between the areas of EC-CFUs treated with various oxygen treatments or with apocynin. (C) Representative photomicrographs of EC-CFUs microscopic fields (X10) for Norm, IH and SH with and without apocynin or DPI. EC-CFUs colonies are indicated by arrows.