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. 2018 Jun 14;9:1294. doi: 10.3389/fimmu.2018.01294

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Copyright © 2018 Ren, Sekine-Kondo, Tateyama, Kasetthat, Wongratanacheewin and Watarai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD1d restricted cells in iPSC-invariant natural killer T (iNKT)-derived cloned mice and iNKT cell subtypes in the thymus of B6 mice. (A) Percentage of CD1d-restricted α-GalCer/CD1d dimer⁺TCRβ⁺ cells positive for the indicated cell surface molecules in WT B6, Trav11-Traj18^+/+ and Cd1d1^−/−Trav11-Traj18^+/+ mice. (B) The iNKT cell subtypes previously characterized in the thymus of B6 mice. Their phenotypes and developmental pathways in the thymus are also shown. Function of iNKT cells is acquired through the development in the thymus distinct from conventional αβ T cells. All of the iNKT subtypes may arise from the CD1d-restricted α-GalCer/CD1d dimer⁺TCRβ⁺ cells in Cd1d1^−/−Trav11-Traj18^+/+ mice in panel (A), while it still remains to be elucidated which signals control the divergence of iNKT1, iNKT2, and iNKT17 subsets.