Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 14;9:1231. doi: 10.3389/fimmu.2018.01231

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Horrevorts, Duinkerken, Bloem, Secades, Kalay, Musters, van Vliet, García-Vallejo and van Kooyk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Toll-like receptor 4 (TLR4) triggering affects the routing of DC-SIGN and its ligand. (A) Time-course of the expression levels of DC-SIGN at both the mRNA and protein level after TLR4 [lipopolysaccharide (LPS)] stimulation of monocyte-derived DCs. (B) Time-course of the internalization score of DC-SIGN after treatment with a TLR4 ligand (LPS). (C) Internalization score of AF405-labeled AZN-D1 after a 60-min incubation at 4°C or a 15-min incubation at 37°C. (D) Time-course of the fluorescence signal intensity of AF405-labeled AZN-D1 (E) Co-localization scores (relative to no LPS) of AF405-labeled AZN-D1 with LAMP1, 60 min after triggering. Mean ± SEM (n > 5,000). *P < 0.01 compared to no LPS.