Table 1.
Effects of hormonal imbalance upon thymocytes during Trypanosoma cruzi infection.
| GC | DHEA | PRL | GH | Testo | Leptin (*) | Reference | |
|---|---|---|---|---|---|---|---|
| Weight/size | ↓ | ↑ | ↑ | ↑ | ↓ | ↓ | (18, 42, 44, 45, 53, 104) |
| Cellularity | ↓ | ↑ | ↑ | ↑ | ↓ | ↓ | (25, 42, 44, 46, 54, 55, 66, 73, 88, 104) |
| Apoptosis of DP cells | ↑ | ↓ | ↓ | ↓ | ↑ | ↓ | (25, 42, 44, 46, 54, 55, 73, 87, 88, 104) |
| Loss of Tregs | ↑ | ND | ND | ND | ND | ND | (66) |
| Vβ T-cell repertoire/negative selection | ND | ND | ND | ND | ND | ND | (19, 67) |
| Altering intrathymic cell migration | ND | ND | ND | ND | ND | ND | (21, 66, 69, 80) |
| Escape of DP/DN cells to periphery | ND | ND | ↓ | ND | ND | ND | (11, 55, 64, 67, 89, 105) |
DP, CD4+CD8+ double-positive; GC, glucocorticoids; DHEA, dehidroepiandrosterone; PRL, prolactin; GH, growth hormone; Testo, testosterone; ND, not determined; ↑, increase; ↓, decrease; (*) effects caused by administration.