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. 2018 Jun 14;12:119. doi: 10.3389/fnbeh.2018.00119

Figure 2.

Figure 2

Spike amplitude attenuation of PL-mPFC pyramidal neurons is reduced in HR rats and correlates with intrinsic excitability. (A) Representative waveforms showing a current-evoked depolarizing step. (B) Current was adjusted so that roughly 15 action potentials fired per sweep. (C) The amplitude of the last, but not first, action potential had higher amplitude in neurons from HR rats vs. neurons from naïve and LR rats. (D) Spike amplitude attenuation in PL-mPFC pyramidal neurons from each rat correlated with CPP scores. Inset shows that spike amplitude attenuation was reduced in HR rats vs. neurons from naïve and LR rats. (E–G) Spike amplitude attenuation correlated with the maximum number of action potentials fired in each neuron for naïve rats (E), LR rats (F) and HR rats (G). Line and bar graphs represent the mean ± SEM. HR, high retrieval; LR, low retrieval; *p < 0.05 vs. control.