Figure 3.

NE enhances PL-mPFC neuronal excitability via cAMP-dependent sAHP inhibition. (A) Representative waveforms showing current-evoked action potentials before (top) and after (bottom) application of NE. (B) NE increased the number of spikes per sweep, an effect that was blocked by inhibition of cAMP-dependent signaling. (C) Representative sAHP waveforms before and after application of NE. (D) NE reversed the sAHP into a slow afterdepolarization, an effect that was blocked by inhibition of cAMP-dependent signaling. Line and bar graphs represent the mean ± SEM. NE, norepinephrine; cAMP⁽⁻⁾, inhibitor of cAMP-dependent signaling (Rp-2’-O-MB-cAMPs); sAHP, slow afterhyperpolarization; **p < 0.01 vs. control.