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Polyamine molecules have broad spectrum efflux pump inhibitor activity. P. aeruginosa (1419) (A) or A baumannii (1643) (B) cells were treated with a sub-lethal concentration of ethidium bromide (25 μM) in combination with tetracycline, the known efflux inhibitor PAβN, lead polyamine agents at 25 μg mL-1, or vehicle (10% DMF) (ND). Graphs demonstrate fluorescence after 90-min exposure displayed as relative fluorescent units. Error bars are shown ± SEM.
