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. 2018 Jun 14;9:1301. doi: 10.3389/fmicb.2018.01301

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Copyright © 2018 Fleeman, Debevec, Antonen, Adams, Santos, Welmaker, Houghten, Giulianotti and Shaw.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polyamines do not destabilize prokaryotic or eukaryotic membranes. (A) Shown is the change in fluorescence of P. aeruginosa (1419) cells using a Disc3 dye assay. Data is presented as change in fluorescence before and after addition of leads compounds, PAβN, and nisin at 25 μg mL^-1. (B) Calcium channel activity assays to assess inhibition of calcium channel pumps in HEK 293 cells after the addition of polyamines 250, 266, 271 or the positive control verapamil at 25 μg mL^-1. Data is presented as change in fluorescence of cells before and after addition of the Fluo-4 dye. No drug (ND) and/or chloramphenicol (CM) were used as negative controls. Error bars are shown ± SEM.