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Polyamine efflux pump inhibitors strongly enhance the bactericidal activity of tetracycline. P. aeruginosa (1419) cells were treated with tetracycline at 0, 12, 25, and 50 μM in combination with no drug (ND), or 247, 250, 266, 271, 314 and PAβN at 25 μg mL-1. The dotted line on the graph denotes 90% bactericidal activity. Data is from at least three biological replicates, with error bars shown ± SEM.
