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. 2018 Jun 20;38(25):5807–5825. doi: 10.1523/JNEUROSCI.3565-17.2018

Figure 6.

Figure 6.

Peripheral CAPS is not required for SNI mechanical and thermal hypersensitivity. A–C, Mice were administered intraplantar CGRP8–37 (533 μm) or PBS each test day 45 min before testing. A, Measurement of paw withdrawal threshold using the von Frey up-down method. CGRP8–37 had no effect on mechanical hypersensitivity in SNI animals or sham controls. B, Measurement of cold sensitivity using the cold plantar assay. CGRP8–37 had no effect on the SNI-induced cold hypersensitivity in SNI or sham animals. C, Measurement of sensitivity to a radiant heat source using the Hargreaves paw withdrawal assay. CGRP8–37 had no effect on heat hypersensitivity in SNI or sham animals. Vertical red dashed line indicates when SNI surgery was performed. Red asterisks indicate significant differences between naïve and SNI surgery. Black asterisks indicate significant differences between naïve and SNI animals treated with CGRP8–37. Data are mean ± SEM and analyzed using three-way ANOVA; n = 8 animals for each treatment group. ****p < 0.0001, **p < 0.005, *p < 0.05. ns, Not significant (p > 0.05).