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. 2018 Jun 14;9:718. doi: 10.3389/fphys.2018.00718

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Copyright © 2018 Martinez, Walton, Bayer, Haïssaguerre, Vigmond, Hocini and Bernus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Greater resistance of Purkinje network to ischemia. (A) Mean ± SD EPI APD across all pacing locations at 1 Hz, before and after 7 min of ischemia. CTL, control; ISC, ischemia. (B) Mean ± SD APD from ENDO and EPI surfaces for each stimulus location stimulation at 1 Hz (before and after ISC). (C) Transmural differences of APD when pacing ENDO, EPI, and PF at 1 Hz, before and after ISC. (D) Mean ± SD PMJ APD (upper panel) and corresponding AP traces (lower panel), as in Figure 3, are shown for all pacing locations, before and after ISC. Statistical differences were determined by paired t-tests (^∗p < 0.05).