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. 2018 Jun 14;9:718. doi: 10.3389/fphys.2018.00718

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Copyright © 2018 Martinez, Walton, Bayer, Haïssaguerre, Vigmond, Hocini and Bernus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impact of pacing sequence on dispersion of repolarization during acute ischemia. (A) RT endocardial and epicardial maps for the different pacing modalities in control conditions and after 7 min of ischemia. Stimulation sites are indicated by (^∗) and black circle shows PMJ location for all pacing sites. Isochrones are 10 ms spacing. CTL, control; ISC, ischemia. (B) Mean ± SD global RT dispersion when pacing ENDO, EPI, and PF at 1 Hz, before and after ISC. Statistical differences were determined by two-way ANOVA (^∗p < 0.05). (C) Mean ± SD local RT dispersion at PMJs compared to endocardium, before and after ISC. Statistical differences were determined by paired t-test (^∗p < 0.05).