Table 1.
Parameter modifiers for ionic models. Modifications were based upon a previous study (Walton et al., 2014) but GCa and GNa currents were modified to obtain similar APD values of experimental findings.
| Control |
Ischemia |
||||
|---|---|---|---|---|---|
| Flags | Purkinje | ENDO | EPI | ENDO | EPI |
| GNa | ×2.94 | ×0.8 | ×0.8 | ||
| GCaL | ×0.8 | ×0.8 | |||
| D_CaL_off | -5.0 | ||||
| Gto | ×3.0 | ×0.5 | ×0.5 | ||
| GK1 | ×0.7 | ×0.7 | |||
| Gks | ×0.2 | ×0.55 | ×0.9 | ×0.55 | ×0.9 |
| Gkr | ×0.2 | ×0.55 | ×0.9 | ×0.55 | ×0.9 |
| Xr2_off | -8.0 | ||||
| knak | ×0.2 | ||||
| knaca | ×0.3 | ||||
| GpCa | ×11.0 | ×0.2 | ×0.2 | ||
| GpK | ×6.0 | ×0.5 | ×0.5 | ||
| Vrel | ×0.6 | ||||
| Vmaxup | ×0.6 | ||||
| GbCa | ×0.2 | ||||
| Ko | 5.4 | 5.4 | 5.4 | 8.0 | 8.0 |
| F_ATP | 0.0 | 0.0 | 0.0 | ×0.08 | ×0.08 |
D_CaL_off, voltage-shift of inactivation of D-type Ca2+ current; F_ATP, binding kinetics of ATP to the potassium ATPase pump; GbCa, conductance of background Ca2+; GCaL, L-type Ca2+ conductance; GNa, Na+ current conductance; Gkr, rapid K+ conductance; Gks, slow K+ conductance; GK1, inward rectifier K+ conductance; GpCa, flux of the Ca2+ pump; GpK, conductance of the K+ pump; Gto, transient outward conductance; knaca, flux of the Na+–Ca2+ exchanger; knak, flux of Na+-K+ exchanger; Ko, extracellular potassium ion concentration; Vmaxup, flux of Ca2+ uptake in to the SR; Vrel, flux of triggered Ca2+ release from the sarcoplasmic reticulum (SR) compartment; xr2_off, voltage-shift of inactivation of rapid K+ current.