Table 2.
The KEGG pathways by the DAVID database for the target list of Danu in Hep3B cells
| Pathway | Gene count | P-Value | Fold Enrichment | |
|---|---|---|---|---|
| 1 | Spliceosome | 26 | 5.24×10-10 | 4.34 |
| 2 | Aminoacyl-tRNA biosynthesis | 12 | 1.93×10-6 | 6.15 |
| 3 | Ribosome | 17 | 2.28×10-6 | 4.11 |
| 4 | Pathogenic Escherichia coli infection | 11 | 2.86×10-4 | 4.06 |
| 5 | Glycolysis / Gluconeogenesis | 11 | 4.40×10-4 | 3.85 |
| 6 | Antigen processing and presentation | 12 | 1.68×10-3 | 3.04 |
| 7 | Methane metabolism | 4 | 1.89×10-3 | 14.01 |
| 8 | Fatty acid metabolism | 8 | 2.39×10-3 | 4.20 |
| 9 | Cysteine and methionine metabolism | 7 | 4.67×10-3 | 4.33 |
| 10 | Pentose phosphate pathway | 6 | 5.58×10-3 | 5.04 |
| 11 | Proteasome | 8 | 6.10×10-3 | 3.58 |
| 12 | Citrate cycle (TCA cycle) | 6 | 1.41×10-2 | 4.07 |
| 13 | Oocyte meiosis | 12 | 1.44×10-2 | 2.29 |
| 14 | Prion diseases | 6 | 2.32×10-2 | 3.60 |
| 15 | Tight junction | 13 | 2.42×10-2 | 2.04 |
| 16 | Glutathione metabolism | 7 | 2.94×10-2 | 2.94 |
| 17 | Pyruvate metabolism | 6 | 3.89×10-2 | 3.15 |
| 18 | Tryptophan metabolism | 6 | 3.89×10-2 | 3.15 |
| 19 | Systemic lupus erythematosus | 10 | 4.39×10-2 | 2.12 |
| 20 | Regulation of actin cytoskeleton | 17 | 4.77×10-2 | 1.66 |
| 21 | Fatty acid elongation in mitochondria | 3 | 5.18×10-2 | 7.88 |
| 22 | Focal adhesion | 16 | 5.2×10-2 | 1.67 |
| 23 | Cell cycle | 11 | 7.13×10-2 | 1.85 |
| 24 | Base excision repair | 5 | 8.16×10-2 | 3.00 |
Abbreviations: KEGG, Kyoto encyclopedia of genes and genomes; Danu, danusertib