Figure 5.

ARA290 treatment Ameliorates Lupuslike symptoms in MRL/lpr Mice. (A‐H), ARA290 (500 μg/kg/d, 3 times/wk, n = 6) or PBS (n = 6) treatment of MRL/lpr mice. Following treatment, serum ANA and ADA concentrations (B), Histological score for glomerular tuft according to H&E staining (C), kidney function (D, E), bodyweight (F), serum cytokine concentrations (G), and the spleen and lymph node weights (H) were measured. Scale bars represent 30 μm. *: P < .05 compared to their respective vehicle control