Table 6.
Other biological activities of GLPS
| Function | Models | Groups | Test indicator | References | |
|---|---|---|---|---|---|
| Facial paralysis | Patients: 20 (13 males/7 females) | 10, Ling Bao Duo Tang Injection | After combination, glucocorticoid dosage reduced, reduced fast, course of treatment shorted and completely healed | 71 | |
| + prednisone | Forehead symptom disappeared, mouth askew and other conditions improved significantly compared with before treatment | ||||
| 10, prednisone + VB1, VB12 | In muscle function after four weeks of combination, there are very significant differences in the muscle function (P < .01) | ||||
| Lumbar hyperplasia | 180 patients | 90, acupoint injection of Ji Sheng | Efficacy: 98.9% | 74 | |
| 30, Ji Sheng Injection | 73.4% | ||||
| 60, electrotherapy | 96.7% | ||||
| Lumbocrural pain | 114 (39 males/75 females) | 58(18/40), Ji Sheng + VB12 | 79.3% | 75 | |
| 56(21/35), Stauntonia + VB12 | 64.3%, (P > .05) | ||||
| Depression | SD rats (8/group) | Normal control, depression | Level of 5‐HT, NE and DA increased than depression group (P < .05) | 70 | |
| Normal saline, GLPS | After treatment of GLPS 28 days, level of 5‐HT, NE and DA were equal to normal (P > .05) | ||||
| Cardiac protection | Wistar rats (10/group) | Modified Euro‐Collins solution (mEC) | Cardiac function and coronary flow were significantly better than mEC (P < .01) | 72 | |
| mEC + Ji Sheng Injection | The content of water and Malondialdehyde, in myocardium, was lower than mEC (P < .05) | ||||
| Activity of LDH and CK was lower than mEC (P < .01), and SOD was higher (P < .05) | |||||
| Heart protection | Kunming mice (10/group) | Ji Sheng Injection‐L (400 mg/L) | Cardiac function and coronary flow were significantly better in three groups of Ji Sheng than mEC, especially in Ji Sheng‐H | 73 | |
| Ji Sheng Injection‐M (800 mg/L) | The content of water in myocardium in Ji Sheng‐M/H was lower than mEC (P < .01) | ||||
| Ji Sheng Injection‐H (1600 mg/L) | Resurrection of heart rate was higher than mEC (P < .01) | ||||
| Sedative and hypnotic | Kunming mice (10/group) | Normal control, sodium pentobarbital + Ji Sheng Injection, Valium, Ji Sheng Injection | Extend sleeping time when administered along with sodium pentobarbital and sodium pentobarbital in a dose‐dependent manner | 77 | |
| Drug independence for Ji Sheng, but for Valium | |||||
| Abnormal locomotor activity is significantly decreased | |||||
| Prolonged sleeping time | SD rats | Prolong sleeping time and improve sleeping quality | 76 | ||
| Anti‐radiation | Mice | Leucocyte/×109/L | SOD/(U/mL) | 79 | |
| Normal control | 12.28 ± 2.51 | 411.07 ± 9.18 | |||
| Radiation | 1.41 ± 0.26 | 357.39 ± 13.52 | |||
| GLPS | 1.92 ± 0.55 | 397.16 ± 5.92 | |||
| Anti‐radiation | Mouse | Leucocyte/×109/L | 78 | ||
| Normal control | 12.08 ± 1.15 | ||||
| Radiation | 2.14 ± 1.83 | ||||
| GLPS | 2.37 ± 1.48 | ||||
| Antibacterial | Inhibited Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Salmonella | 80 | |||
| Antibacterial | Inhibited Bacillus subtilis, Escherichia coli, Staphylococcus aureus and Salmonella | 81 | |||
| Antibacterial | A strong inhibiting effect on Erwinia carotovora and a weak inhibiting effect on Penicillium digitatum | 82 | |||
| Blood stasis | Kunming mice | Prolonged clotting time and reduced serum TG levels in hyperlipidaemia mice inhibited thrombus formation in vitro | 86 | ||
| Wistar rats | |||||
| Hepatoprotective | BALB/c mouse | Significantly mitigated hepatic tumefaction and decreased both ALT release and NO production | 84 | ||
| STZ‐induced diabetic nephropathy | C57BL/6J mouse | Reduced the serum Cr and BUN levels and oxidative stress | 85 | ||
| Anti‐skin ageing | SD rats (10/group) | Enhanced both hydroxyproline and SOD contents in a GLPS dose‐dependent manner | 83 | ||
| Protective roles on bleomycin‐induced pulmonary fibrosis | SD rats | Increased levels of glutathione, glutathione peroxidase, catalase and superoxide dismutase and decreased contents of malondialdehyde and hydroxyproline in the lung | 90 | ||
| Chronic pancreatitis | ICR mice | Alleviated the pancreatitis in mice through decreasing lipase, AMS, IFN‐γ and TNF‐α levels as well as increasing SOD and total antioxidant activity | 91 | ||
GLPS, Ganoderma lucidum polysaccharides; SOD, Superoxide dismutase.