Figure 1.

HGF induced gefitinib resistance and down‐regulated expression of miR‐1‐3p and miR‐206 in lung adenocarcinoma PC‐9 and HCC827 cells. A‐B, HGF induced gefitinib resistance in PC‐9 (A) and HCC827 (B) cells. Tumour cells were incubated with increasing concentrations of gefitinib in the presence/absence of HGF, and cell viability was determined after 72 h of treatment by MTT assay. Data are means of three separated experiments ± SD, **P < .01 compared with gefitinib group. C‐D, HGF‐induced down‐regulated expression of miR‐1‐3p and miR‐206 in PC‐9 (C) and HCC827 cells (D). Tumour cells were incubated with HGF (50 ng/mL) for 72 h, the expression of miR‐1‐3p and miR‐206 were determined by QPCR assay. Data are means of three separated experiments ± SD, **P < .01 compared with control group