. 2018 May 2;7(6):2307–2318. doi: 10.1002/cam4.1475

Table 2.

The association between clinical characteristics of Paget disease and marital status

Categories		Married (n)	Unmarried (n)	Unknown (n)	P‐value
				PD
Age at diagnosis (years)	18–49	69	36	9	0.002
Age at diagnosis (years)	50–79	147	168	40	0.002
Race	White	187	170	36	0.027
	Black	16	24	5
	Other	13	10	8
Laterality	Left	109	113	15	0.004
	Right	107	86	33
	Paired site	0	5	1
	Unknown	0	0	0
Tumor size (cm)	<2	16	25	13	<0.001
	2.1–5	134	101	14
	>5	0	5	4
	Unknown	66	73	18
Lymph node status	Negative	84	69	5	0.001
Lymph node status	Positive	132	135	44	0.001
Grade	I	6	5	0	0.523
	II	10	13	0
	III	22	14	5
	IV	2	1	0
	Unknown	176	171	44
AJCC stage	0	49	28	6	0.177
	I	7	3	1
	II	0	1	1
	III	2	2	0
	IV	2	1	0
	Unknown	156	169	41
ER status	Negative	33	34	7	0.249
	Positive	38	26	3
	Borderline	145	144	39
	Unknown	216	204	49
PR status	Negative	48	39	8	0.641
	Positive	18	17	2
	Borderline	0	0	0
	Unknown	150	148	39
HER2 status	Negative	4	3	0	0.695
	Positive	10	6	1
	Borderline	0	0	0
	Unknown	202	195	48
Radiation	No	174	173	37	<0.001
	Yes	36	27	4
	Unknown	6	4	8
		PD‐IDC
Age at diagnosis (years)	18–49	407	240	18	<0.001
Age at diagnosis (years)	50–79	496	616	55	<0.001
Race	White	740	653	53	<0.001
	Black	58	137	11
	Other	105	66	9
Laterality	Left	481	443	35	0.715
	Right	422	412	38
	Paired site	0	1	0
	Unknown	0	0	0
Tumor size (cm)	<2	14	23	4	0.189
	2.1–5	553	506	39
	>5	14	14	0
	Unknown	322	313	30
Lymph node status	Negative	407	366	34	0.562
Lymph node status	Positive	496	490	39	0.562
Grade	I	43	67	3	0.169
	II	266	236	24
	III	498	469	36
	IV	25	18	1
	Unknown	71	66	9
AJCC stage	0	1	3	0	0.411
	I	86	60	7
	II	45	58	3
	III	49	41	5
	IV	13	8	0
	Unknown	709	686	58
ER status	Negative	397	347	25	0.01
	Positive	424	391	34
	Borderline	3	8	0
	Unknown	79	110	14
PR status	Negative	492	456	35	0.006
	Positive	314	279	20
	Borderline	5	4	2
	Unknown	92	117	16
HER2 status	Negative	56	63	4	0.025
	Positive	114	88	8
	Borderline	5	1	2
	Unknown	728	704	59
Radiation	No	634	660	45	<0.001
	Yes	244	174	17
	Unknown	16	22	11
Age at diagnosis (years)	18–49	407	240	18	<0.001
Age at diagnosis (years)	50–79	496	616	55	<0.001
Race	White	740	653	53	<0.001
	Black	58	137	11
	Other	105	66	9
Laterality	Left	481	443	35	0.715
	Right	422	412	38
	Paired site	0	1	0
	Unknown	0	0	0
Tumor size (cm)	<2	14	23	4	0.189
	2.1–5	553	506	39
	>5	14	14	0
	Unknown	322	313	30
Lymph node status	Negative	407	366	34	0.562
Lymph node status	Positive	496	490	39	0.562
Grade	I	43	67	3	0.169
	II	266	236	24
	III	498	469	36
	IV	25	18	1
	Unknown	71	66	9
AJCC stage	0	1	3	0	0.411
	I	86	60	7
	II	45	58	3
	III	49	41	5
	IV	13	8	0
	Unknown	709	686	58
ER status	Negative	397	347	25	0.01
	Positive	424	391	34
	Borderline	3	8	0
	Unknown	79	110	14
PR status	Negative	492	456	35	0.006
	Positive	314	279	20
	Borderline	5	4	2
	Unknown	92	117	16
HER2 status	Negative	56	63	4	0.025
	Positive	114	88	8
	Borderline	5	1	2
	Unknown	728	704	59
Radiation	No	634	660	45	<0.001
	Yes	244	174	17
	Unknown	16	22	11

AJCC, American Joint Committee on Cancer; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; IDC, infiltrating duct carcinoma; PD‐IDC, Paget disease concomitant infiltrating duct carcinoma; PD‐DCIS, Paget disease concomitant intraductal carcinoma, unmarried group included divorced, separated, single (never married), and widowed.