Table 4.
Survival analyses–multivariate analyses of Paget disease
| Variables | Category | Hazard ratio | 95% Confidence interval | P‐value |
|---|---|---|---|---|
| PD | ||||
| Age at diagnosis (years) | 18–49 | 1 | Referent | 0.005 |
| 50–79 | 0.449 | 0.257–0.787 | ||
| Race | White | 1 | Referent | 0.014 |
| Black | 3.772 | 1.366–10.413 | ||
| Other | 5.495 | 1756–17.2 | ||
| Marital status | Married | 1 | Referent | <0.001 |
| Not married | 0.379 | 0.214–0.672 | ||
| Unknown | 0.887 | 0.528–1.491 | ||
| Tumor size (cm) | <2 | 1 | Referent | 0.033 |
| 2.1–5 | 1.417 | 0.806–2.494 | ||
| >5 | 0.651 | 0.429–0.988 | ||
| Unknown | 1.506 | 0.509–4.454 | ||
| Lymph node status | Negative | 1 | Referent | <0.001 |
| Positive | 0.417 | 0.264–0.658 | ||
| Grade | I | 1 | Referent | 0.042 |
| II | 1.065 | 0.3–2.86 | ||
| III | 2.537 | 1.239–5.139 | ||
| IV | 0.714 | 0.313–1.628 | ||
| Unknown | 1.404 | 0.189–10.436 | ||
| AJCC stage | 0 | 1 | Referent | 0.203 |
| I | 0.795 | 0.353–1.793 | ||
| II | 0 | 0 | ||
| III | 0 | 0 | ||
| IV | 1.613 | 0.204–12.763 | ||
| Unknown | 5.224 | 1.449–18.837 | ||
| PD‐IDC | ||||
| Age at diagnosis (years) | 18–49 | 1 | Referent | <0.001 |
| 50–79 | 0.347 | 0.283–0.425 | ||
| Race | White | 1 | Referent | 0.77 |
| Black | 0.556 | 0.813–1.47 | ||
| Other | 0.472 | 0.795–1.643 | ||
| Marital status | Married | 1 | Referent | <0.001 |
| Not married | 0.625 | 0.427–0.914 | ||
| Unknown | 1.053 | 0.728–1.523 | ||
| Tumor size (cm) | <2 | 1 | Referent | <0.001 |
| 2.1–5 | 2.537 | 1.662–3.873 | ||
| >5 | 0.915 | 0.769–1.088 | ||
| Unknown | 1.255 | 0.685–2.302 | ||
| Lymph node status | Negative | 1 | Referent | <0.001 |
| Positive | 0.437 | 0.366–0.522 | ||
| Grade | I | 1 | Referent | 0.049 |
| II | 0.696 | 0.439–1.103 | ||
| III | 0.946 | 0.683–1.311 | ||
| IV | 1.155 | 0.855–1.561 | ||
| Unknown | 0.855 | 0.705–2.256 | ||
| AJCC stage | 0 | 1 | Referent | <0.001 |
| I | 0 | 0 | ||
| II | 0.548 | 0.256–1.172 | ||
| III | 0.67 | 0.329–1.364 | ||
| IV | 1.055 | 0.632–1.764 | ||
| Unknown | 4.754 | 2.48–9.112 | ||
| ER status | Negative | 1 | Referent | 0.034 |
| Positive | 0.453 | 0.195–1.052 | ||
| Borderline | 0.438 | 0.19–1.007 | ||
| Unknown | 1.329 | 0.373–4.732 | ||
| PR status | Negative | 1 | Referent | 0.212 |
| Positive | 2.12 | 0.931–4.827 | ||
| Borderline | 1.818 | 0.799–4.138 | ||
| Unknown | 2.477 | 0.66–9.29 | ||
| PD‐DCIS | ||||
| Age at diagnosis (years) | 18–49 | 1 | Referent | <0.001 |
| 50–79 | 0.309 | 0.203–0.469 | ||
| Race | White | 1 | Referent | 0.63 |
| Black | 1.058 | 0.619–1.808 | ||
| Other | 1.288 | 0.67–2.475 | ||
| Marital status | Married | 1 | Referent | <0.001 |
| Not married | 0.504 | 0.269–0.945 | ||
| Unknown | 1.237 | 0.675–2.266 | ||
| Tumor size (cm) | <2 | 1 | Referent | <0.001 |
| 2.1–5 | 4.82 | 2.351–9.88 | ||
| >5 | 1.035 | 0.772–1.388 | ||
| Unknown | 1.617 | 0.218–11.983 | ||
| Lymph node status | Negative | 1 | Referent | <0.001 |
| Positive | 0.546 | 0.424–0.704 | ||
| Grade | I | 1 | Referent | 0.332 |
| II | 0.35 | 0.085–1.447 | ||
| III | 0.74 | 0.457–1.198 | ||
| IV | 0.891 | 0.663–1.198 | ||
| Unknown | 0.786 | 0.569–1.088 | ||
| ER status | Negative | 1 | Referent | 0.3 |
| Positive | 1.424 | 0.759–2.672 | ||
| Borderline | 0.922 | 0.486–1.749 | ||
| Unknown | 0.968 | 0.23–14.54 | ||
| PR status | Negative | 1 | Referent | 0.898 |
| Positive | 0.857 | 0.467–1.574 | ||
| Borderline | 1.047 | 0.513–2.134 | ||
| Unknown | 0 | 0 | ||
| HER2 status | Negative | 1 | Referent | 0.004 |
| Positive | 9.502 | 2.758–32.734 | ||
| Borderline | 0.614 | 0.084–4.466 | ||
| Unknown | 0 | 0 | ||
| Radiation | No | 1 | Referent | 0.001 |
| Yes | 2.183 | 0.688–6.922 | ||
| Unknown | 1.096 | 0.33–3.638 | ||
AJCC, American Joint Committee on Cancer; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; IDC, infiltrating duct carcinoma; PD‐IDC, Paget disease concomitant infiltrating duct carcinoma; PD‐DCIS, Paget disease concomitant intraductal carcinoma, unmarried group included divorced, separated, single (never married), and widowed.