Figure 3.

a) i) Schematic illustration of NO‐releasing poly(2‐hydroxyethyl methacrylate) (PHEMA) micelles with two different pendant moieties: methoxy poly(ethylene glycol) and poly(lactic acid) (m‐PEG‐PLA) or d‐α‐tocopheryl polyethylene glycol succinate (TPGS). (ii) Cumulative NO release from the two types of PHEMA micelles in PBS (pH 7.4) in the presence of 10 × 10⁻³ m glutathione. Reproduced with permission.44 Copyright 2015, The Royal Society of Chemistry. b) Tumor weight (top) and the corresponding photographs (bottom) of tumor‐bearing mice when treated with saline, nitroglycerine (GTN), TPGS, nitrate‐functionalized TPGS micelles (TNO₃), anticancer drug doxorubicin (DOX), and the combination of DOX and TNO₃. The codelivery of DOX and TNO₃ leads to better antitumor efficacy. Reproduced with permission.45 Copyright 2014, American Chemical Society.