Figure 8.
a) Schematic illustration of photoresponsive NO‐releasing metal–organic frameworks (MOFs): Zn(2nIm)2 (NOF‐1) and Zn(mnIm)2 (NOF‐2). b) NO release profile of NOF‐1 can be tuned by varying light irradiation time and intensity. c) Top: Schematic illustration of localized NO release from NOF‐1 triggered by two‐photon near‐infrared laser irradiation. The released NO reacts with NO fluorescent indicator, 4‐amino‐5‐methylamino‐2′,7′‐difluorofluorescein (DAF‐FM), generating green fluorescent signal. Bottom: Confocal microscope image demonstrating the selective photoactivation of NOF‐1 on human embryonic kidney 293 (HEK293) cell culture. Scale bar: 100 µm. d) Further demonstration of spatiotemporal control activation of NOF‐1. Scale bar: 100 µm. Reproduced with permission.80 Copyright 2013, Nature Publishing Group.