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Epirubicin and celecoxib combined therapy blocks angiogenesis, cancer stemness, and drug efflux in Novikoff hepatoma. Immunohistochemistry analysis for (A) CD31, (B) CD44, (C) CD133, and (D) MDR‐1 from tumor tissues after therapy for 7 days (red arrow indicates blood vessels in the tumor tissues). Data were mean ± SD (n.s. = no significance, *P < 0.05, **P < 0.01). Scale bar = 200 μm in CD31 analysis. Scale bar = 50 μm in CD44, CD133, and MDR‐1 analysis.
