Table 2.
XPA expression in CRC and nontumor adjacent tissues
| Category | Group | Cases | (−) | (+) | (++) | (+++) | PR (%) | P |
|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | |||||
| Overall | CRC | 275 | 11 (4.0) | 120 (43.6) | 108 (39.3) | 36 (13.1) | 96.0 | 0.001 |
| Adjacent | 275 | 27 (9.8) | 64 (23.3) | 123 (44.7) | 61 (22.2) | 90.2 | ||
| Male | CRC | 161 | 7 (4.3) | 72 (44.7) | 59 (36.6) | 23 (14.3) | 95.7 | 0.004 |
| Adjacent | 161 | 17 (10.6) | 36 (22.4) | 70 (43.5) | 38 (23.6) | 89.4 | ||
| Female | CRC | 114 | 4 (3.5) | 48 (42.1) | 49 (43.0) | 13 (11.4) | 96.5 | 0.067 |
| Adjacent | 114 | 10 (8.8) | 28 (24.6) | 53 (46.5) | 23 (20.2) | 91.2 | ||
| ≤60 | CRC | 130 | 5 (3.8) | 65 (50.0) | 43 (33.1) | 17 (13.1) | 96.2 | 0.008 |
| Adjacent | 130 | 14 (10.8) | 29 (22.3) | 63 (48.5 | 24 (18.5) | 89.2 | ||
| >60 | CRC | 145 | 6 (4.1) | 55 (37.9) | 65 (44.8) | 19 (13.1) | 95.9 | 0.026 |
| Adjacent | 145 | 13 (9.0) | 35 (24.1) | 60 (41.4) | 37 (25.5) | 91.0 | ||
| Colon | CRC | 78 | 2 (2.6) | 38 (48.7) | 29 (37.2) | 9 (11.5) | 97.4 | 0.009 |
| Adjacent | 78 | 9 (11.5) | 15 (19.2) | 38 (48.7) | 16 (20.5) | 88.5 | ||
| Rectum | CRC | 196 | 9 (4.6) | 82 (41.8) | 78 (39.8) | 27 (13.8) | 95.4 | 0.015 |
| Adjacent | 196 | 18 (9.2) | 48 (24.5) | 85 (43.4) | 45 (23.0) | 90.8 |
PR, positive rate. Negative (−), light positive (+), positive (++), strong positive (+++) staining. Mann–Whitney U‐test of nonparametric test to compare the XPA protein expression between CRC and adjacent tissues.
The bold values: P<0.05