Table 5.
Differences in biological markers in patients and controls below and above 45 years of age.
| Patients | Controls | |||||
|---|---|---|---|---|---|---|
| <45 y (n = 36) | ≥45 y (n = 31) | Effect | <45 y (n = 19) | ≥45 y (n = 16) | Effect | |
| Trp (μmol/l) | 52.91 (1.35) | 48.70 (1.8) | F(61.6) = 5.3; p = 0.025; b = 4.21 | 53.81 (1.30) | 55.15 (1.34) | F(150) = 0.8; p = 0.369; b = −1.34 |
| Kyn (μmol/l) | 1.43 (0.05) | 1.51 (0.06) | F(63.5) = 1.0; p = 0.311; b = −0.08 | 1.57 (0.05) | 1.59 (0.05) | F(181) = 0.1; p = 0.700; b = −0.02 |
| Kyn/Trp (μmol/mmol) | 27.20 (0.91) | 31.30 (0.99) | F(65.0) = 9.4; p = 0.003; b = −4.09 | 29.71 (0.87) | 29.08 (0.90) | F(180.5) = 0.5; p = 0.468; b = 0.64 |
| Neo (nmol/l) | 4.78 (0.18) | 5.41 (0.20) | F(67.5) = 5.5; p = 0.022; b = −0.63 | 5.15 (0.22) | 4.94 (0.23) | F(88.8) = 0.6; p = 0.457; b = 0.22 |
| Tyr (μmol/l) | 64.05 (2.50) | 66.34 (2.69) | F(60.6) = 0.5; p = 0.498; b = −2.28 | 76.70 (4.00) | 73.12 (4.14) | F(179.7) = 0.8; p = 0.378; b = 3.52 |
| Phe (μmol/l) | 50.97 (1.26) | 50.27 (1.37) | F(58.2) = 0.2; p = 0.695; b = 0.69 | 55.89 (1.85) | 55.88 (1.92) | F(169.7) = 0.0; p = 0.998; b = 0.01 |
| Phe/Tyr | 0.83 (0.02) | 0.79 (0.02) | F(64.8) = 1.3; p = 0.250; b = 0.04 | 0.77 (0.02) | 0.78 (0.03) | F(160.7) = 0.1; p = 0.757; b = −0.01 |
| IFN-y (pg/ml)* | 4.66 (0.10) | 4.94 (0.09) | F(56.7) = 0.2; p = 0.683; b = −0.06 | 5.55 (0.13) | 4.29 (0.14) | F(95.5) = 2.0; p = 0.161; b = 0.26 |
| IL-6 (pg/ml)* | 0.41 (0.08) | 0.61 (0.08) | F(62.8) = 12.4; p <0.001; b = −0.41 | 0.42 (0.12) | 0.41 (0.12) | F(136.3) = 0.1; p = 0.774; b = 0.04 |
| TNF-α (pg/ml)* | 1.77 (0.05) | 2.08 (0.06) | F(65.2) = 4.4; p = 0.039; b = −0.16 | 1.74 (0.06) | 1.81 (0.06) | F(174.7) = 0.8; p = 0.378; b = −0.04 |
| CRP (mg/L)* | 1.65 (0.19) | 2.29 (0.20) | F(67.7) = 1.4; p = 0.236; b = −0.33 | 1.41 (0.16) | 1.14 (0.16) | F(154.2) = 1.3; p = 0.260; b = 0.21 |
Data presented as mean (SE).
SE, standard error; IFN-y, interferon gamma; IL, interleukin; TNF-α, tumor necrosis factor alpha; CRP, C-reactive protein; Trp, tryptophan; Kyn, kynurenine; Neo, neopterin; Tyr, tyrosine; Phe, phenylalanine.
*
SE on log-transformed d. Bold values: significant p-values (p < 0.05).